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. 2013 Oct 25;13(1):168–183. doi: 10.1074/mcp.M113.032847

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Fig. 5. — SIRT6 is phosphorylated at conserved residues within a C-terminal naturally disordered region. A, SIRT6 is phosphorylated at multiple sites localized to the N and C terminus of the protein: serine 10 (S10), serine 303 (S303), threonine 294 (T294), serine 330 (S330), and serine 338 (S338). C-terminal sites fall within a proline-rich amino acid sequence. B, SIRT6 is predicted to be natively disordered at its C-terminal region as analyzed by the PONDR algorithm. C, phosphorylated SIRT6 residues (red) are evolutionarily conserved among mammalian organisms. Sequence alignment was generated using NCBI Standard Protein BLAST with the following NCBI protein gi numbers for SIRT6 homologs: Homo sapiens (human) 38258612, Pan troglodytes (chimp) 114674699, Macaca mulatta is2 (monkey is2) 109122957, Canis familiaris (dog) 73987415, Sus scrofa (wild boar) 217331637, Bos taurus (cattle) 296485693, Mus musculus (mouse) 31712018, Rattus norvegicus (rat) 72255525, Macaca mulatta is1 (monkey is1) 109122959, Gallus gallus (chicken) 8612955, Danio rerio (zebrafish) 50344796, Xenopus laevis (frog) 148238219, and Taeniopygia guttata (zebra finch) 224052096.