Fig. 4.

Knockdown of hnRNP K inhibited HCV RNA accumulation in a dose-response manner. A, hnRNP K siRNA was transfected into HCV replicon cells at 0, 20, and 100 nm. At 48 h post-transfection, hnRNP K expression was determined by Western blot. B, Quantitation of HCV RNA levels in cell treated with hnRNP K siRNA. The HCV RNA was quantified by qRT-PCR, and the values were divided by a mock-treated control (0 nm) to generate the percent changes (n = 3).