Table 1.
Clinical, Laboratory, and Radiographic Data
| Age | Bone Age | Height, cm (SDS)a | Weight, kg (SDS)a | HC, cm (SDS)b | IGF-1, ng/mLc | IGFBP-3, mg/Ld | ALS, mg/Le |
|---|---|---|---|---|---|---|---|
| Birth | 47.6 (−1.2) | 2.7 (−1.5) | |||||
| 2.3 y | 26 months (normal) | 77.5 (−3.1) | 8.8 (−3.8) | 43.7 (low/normal) | 2.3 (normal) | ||
| 4.3 y | 4 y (normal) | 91.9 (−2.8) | 12.2 (−3.1) | ||||
| 5.3 y | 6 y (normal) | 96.9 (−2.9) | 14.4 (−2.5) | 46.5 (−3.3) | 58.5 (low/normal) | 4.3 (normal) | 10 (normal) |
| 8.4 y | 8 y (normal) | 114.9 (−2.7) | 21.9 (−1.5) | 47.8 (−3.4) | 100 (normal) | 5.4 (normal) |
a
Height and weight SDSs based on CDC growth curves.
b
Head circumference SDSs.
c
IGF-1 normal ranges per age in Tanner 1 males (ng/mL): age 1–2 years, 30–122; age 5 years, 30–174; and age 8 years, 52–231.
d
IGFBP-3 normal ranges per age in Tanner 1 males (mg/L): age 2 years, 0.8–3.9; age 5 years, 1.1–5.2; age 8 years, 1.6–6.5.
e
ALS, normal range for a male at 5.3 years, 2.3–11 mg/L.