Table 3.

Unadjusted and Fully Adjusted Sclerostin Association Analyses^a

Outcome	All Subjects			Men			Women
	Estimate	SE	P Value	Estimate	SE	P Value	Estimate	SE	P Value
Log (TvBMD)
Model 1	0.180	0.035	<.0001	0.149	0.050	.003	0.245	0.051	<.0001
Model 2	0.263	0.032	<.0001	0.236	0.048	<.0001	0.272	0.043	<.0001
Model 3	0.294	0.048	<.0001	0.274	0.070	.000	0.310	0.070	<.0001
Log (LvBMD)
Model 1	0.181	0.037	<.0001	0.133	0.052	.011	0.249	0.055	<.0001
Model 2	0.265	0.032	<.0001	0.227	0.048	<.0001	0.284	0.043	<.0001
Model 3	0.322	0.048	<.0001	0.258	0.075	.001	0.369	0.067	<.0001
Log (Cor CP + 1)
Model 1	0.746	0.378	.049	0.907	0.572	.115	0.020	0.514	.969
Model 2	−0.110	0.345	.749	−0.234	0.511	.648	−0.123	0.475	.796
Model 3	−0.362	0.502	.472	−0.963	0.807	.236	0.090	0.667	.893
Log (Car CP + 1)
Model 1	0.257	0.285	.368	0.241	0.437	.582	0.026	0.389	.947
Model 2	−0.318	0.269	.238	−0.624	0.406	.126	−0.113	0.364	.757
Model 3	−0.653	0.398	.102	−1.452	0.651	.028	0.136	0.501	.786
Log (Ao CP + 1)
Model 1	0.522	0.447	.244	0.407	0.632	.520	0.316	0.657	.631
Model 2	−0.502	0.393	.202	−0.927	0.564	.102	−0.038	0.554	.946
Model 3	−0.301	0.519	.563	−1.018	0.824	.220	0.612	0.682	.372
Log (ACR)
Model 1	0.538	0.241	.026	0.376	0.341	.272	0.497	0.354	.162
Model 2	0.469	0.250	.061	0.522	0.357	.146	0.489	0.356	.171
Model 3	0.640	0.339	.060	0.870	0.493	.081	0.620	0.485	.204
GFR
Model 1	−20.700	3.636	<.0001	−25.248	5.016	<.0001	−20.094	5.389	.000
Model 2	−19.010	3.589	<.0001	−19.911	5.109	.000	−19.269	5.111	.000
Model 3	−14.849	5.216	.005	−21.393	8.616	.015	−9.010	6.643	.178

Abbreviations: Ao, aortoiliac; Car, carotid artery; Cor, coronary artery.

^aModel 1 is unadjusted. Model 2 is adjusted for age, gender, and BMI. Model 3 is adjusted for age, gender, BMI, low-density lipoprotein-cholesterol, mean arterial BP, smoking status, and HbA_1c.