Figure 2.

Non-decoded mean GH concentrations measured every 10 minutes for 19 hours overnight. Data comprise 6-hour baseline sampling (10:00 pm 4:00 am) followed by 13-hour subsequent sampling with 4 bolus iv ghrelin injections administered in randomized order every 3 hours (5:00 am, 8:00 am, 11:00 am, and 2:00 pm). Ghrelin pulses were superimposed upon constant iv infusions of saline, GHRH, or SS. Data are from 12 women treated with leuprolide plus placebo and 12 others treated with leuprolide plus E₂.