Table 1.
Prevalence estimates and associated 95% confidence intervals for HPV types according to lesion histology.
| HPV Type | Biopsy % positive (95% CI) | Swab % positive (95% CI) | Exact McNemar’s p-value |
|---|---|---|---|
| Condyloma (N=90) | |||
| Any HPV | 96 (91, 100) | 92 (87, 98) | 0.55 |
| HPV 6 | 44 (34, 55) | 62 (51,72) | 0.007 |
| HPV 11 | 34 (25, 45) | 19 (11, 29) | 0.0005 |
| HPV 16 | 2 (0, 8) | 9 (4, 17) | 0.07 |
| HPV 18 | 1 (0, 6) | 6 (2, 12) | 0.22 |
| HPV othera | 6 (2, 12) | 21 (13, 31) | 0.0026 |
| Lesions with indefinite histology (N=42)b | |||
| Any HPV | 86 (75, 96) | 70 (57, 85) | 0.15 |
| HPV 6 | 40 (26, 57) | 43 (28, 59) | 1.00 |
| HPV 11 | 29 (16, 45) | 14 (5, 29) | 0.03 |
| HPV 16 | 10 (3, 23) | 0 | na |
| HPV 18 | 2 (0, 13) | 7 (1, 19) | 0.63 |
| HPV othera | 14 (5, 29) | 19 (9, 34) | 0.77 |
| Non-condyloma (N=23)c | |||
| Any HPV | 91 (80, 100) | 61 (41, 81) | 0.06 |
| HPV 6 | 43 (23, 66) | 26 (1, 48) | 0.29 |
| HPV 11 | 20 (7, 44) | 9 (1, 28) | 0.38 |
| HPV 16 | 9 (1, 28) | 0 | na |
| HPV 18 | 0 | 0 | na |
| HPV othera | 22 (5, 39) | 26 (8, 44) | 1.00 |
| PeIN (N=10) | |||
| Any HPV | 100 (69, 100) | 100 (69, 100) | na |
| HPV 6 | 30 (7, 65) | 20 (3, 56) | 1.00 |
| HPV 11 | 30 (7, 65) | 20 (3, 56) | 1.00 |
| HPV 16 | 60 (26, 88) | 60 (26, 88) | na |
| HPV 18 | 10 (0, 45) | 10 (0, 45) | na |
| HPV othera | 20 (0, 45) | 50 (19, 81) | 0.25 |
CI = confidence interval, PeIN = penile intraepithelial neoplasia.
a
Positive for at least one of the 16 HPV types other than 6/11/16/18 that were tested for in both assays used to genotype the swab and biopsy samples (31, 33, 35, 39, 40, 42, 45, 51-54, 56, 58, 59, 66, and 68).
b
Includes squamous keratosis and benign squamous papilloma.
c
Includes seborrheic keratosis, Molluscum Contagiosum, intradermal nevus, Fibroepithelial polyp (skin tag), chronic balanitis, genital melanotic macule, psoriasiform dermatitis, lichenoid tissue reaction, and acute mucositis.