Table 2.
Concordance of HPV DNA types detected by swabbing the surface of a lesion and obtaining a shave biopsy.
| HPV type | HPV positive in biopsy only | HPV positive in swab only | Biopsy and swab HPV positive | Biopsy and swab HPV negative | (%) Agreement | Kappa (95% CI) |
|---|---|---|---|---|---|---|
| Condyloma (N=90) | ||||||
| Any HPV | 7 | 4 | 79 | 0 | 87.8 | -0.06 (-0.02 - -0.10) |
| HPV 6 | 8 | 24 | 32 | 26 | 64.4 | 0.31 (0.13 - 0.49) |
| HPV 11 | 15 | 1 | 16 | 58 | 82.2 | 0.56 (0.38 - 0.74) |
| HPV 16 | 1 | 7 | 1 | 81 | 91.1 | 0.17 (-0.15 - 0.50) |
| HPV 18 | 1 | 5 | 0 | 84 | 93.3 | -0.02 (-0.05 - 0.01) |
| HPV other | 3 | 17 | 2 | 68 | 77.8 | 0.09 (-0.11 – 0.28) |
| Lesions with indefinite histology (N=42) | ||||||
| Any HPV | 9 | 3 | 27 | 3 | 71.4 | 0.18 (-0.13 - 0.48) |
| HPV 6 | 7 | 8 | 10 | 17 | 64.3 | 0.26 (-0.03 - 0.56) |
| HPV 11 | 6 | 0 | 6 | 30 | 85.7 | 0.59 (0.31 - 0.87) |
| HPV 16 | 4 | 0 | 0 | 38 | 90.5 | na |
| HPV 18 | 1 | 3 | 0 | 38 | 90.5 | 0.04 (-0.09 - 0.02) |
| HPV other | 5 | 7 | 1 | 29 | 71.4 | -0.02 (-0.31, 0.26 |
| Non-condyloma (N=23) | ||||||
| Any HPV | 9 | 2 | 12 | 0 | 52.2 | -0.16 (-0.37 - 0.04) |
| HPV 6 | 6 | 2 | 4 | 11 | 65.2 | 0.26 (-0.12 - 0.64) |
| HPV 11 | 4 | 1 | 1 | 17 | 78.3 | 0.18 (-0.26 - 0.63) |
| HPV 16 | 2 | 0 | 0 | 21 | 91.3 | na |
| HPV 18 | 0 | 0 | 0 | 23 | 100.0 | na |
| HPV other | 3 | 4 | 14 | 2 | 69.6 | 0.16 (-0.27 - 0.60) |
| PeIN (N=10) | ||||||
| Any HPV | 0 | 0 | 0 | 10 | 100.0 | 1.00 (1.00 - 1.00) |
| HPV 6 | 1 | 0 | 2 | 7 | 90.0 | 0.74 (0.26 – 1.00) |
| HPV 11 | 1 | 0 | 2 | 7 | 90.0 | 0.74 (0.26 – 1.00) |
| HPV 16 | 0 | 0 | 6 | 4 | 100.0 | 1.00 (1.00 - 1.00) |
| HPV 18 | 0 | 0 | 1 | 9 | 100.0 | 1.00 (1.00 - 1.00) |
| HPV other | 0 | 3 | 2 | 5 | 70.0 | 0.40 (-0.05, 0.85) |