| Positive regulators of autophagy |
| VPS34 |
catalytic subunit of phosphatidylinositol 3-kinase complexes |
11,155
|
| VPS15 |
cofactor of VPS34 required for production of PtdIns(3)P |
17,151
|
| UVRAG |
promotes autophagy, present in late endosomes |
11,21,156
|
| ATG14 |
promotes autophagy, essential for localization of VPS34 to phagophore |
11,21
|
| AMBRA1 |
promotes autophagy, nutrient-dependent localization of Beclin-1 |
131,157
|
| HMGB1 |
promotes autophagy, increases VPS34 activity |
158 |
| Bif-1 |
promotes autophagy, promotes UVRAG-containing VPS34 complexes |
159 |
| Negative regulators of autophagy |
| Rubicon |
inhibits autophagy, antagonizes UVRAG-containing VPS34 complexes |
16,19
|
| Bcl-2 |
inhibits autophagy, inhibits Beclin-1-containing VPS34 complexes |
142 |
| Bcl-xL |
inhibits autophagy, binds Beclin-1 complexes at the ER |
145 |
| IP3R |
inhibits autophagy, binds Beclin-1 complexes at the ER |
160 |
