Atg1/ULK complex
|
Atg1 |
ULK1/2 |
Ser/Thr protein kinase; phosphorylated by M/TORC1; recruitment of Atg proteins to the PAS |
| Atg13 |
ATG13 |
Regulatory subunit through phosphorylation by M/TORC1 and/or PKA, linker between Atg1 and Atg17 |
| Atg17 |
RB1CC1/FIP200 (functional homolog) |
Scaffold protein, ternary complex with Atg29 and Atg31. Phosphorylated by ULK1; scaffold for ULK1/2 and ATG13 |
| Atg29 |
|
Ternary complex with Atg17 and Atg31 |
| Atg31 |
|
Ternary complex with Atg17 and Atg29 |
| Atg11 |
|
Scaffold protein in selective autophagy for PAS organization |
|
C12orf44/Atg101
|
Component of the complex with ATG13 and RB1CC1
|
Atg9 and its cycling system
|
Atg2 |
ATG2 |
Interacts with Atg18 |
| Atg9 |
ATG9A/B |
Transmembrane protein, directs membrane to the phagophore |
Atg18
|
WIPI1/2
|
PtdIns3P-binding protein
|
PtdIns3K complex
|
Vps34 |
PIK3C3/VPS34 |
PtdIns 3-kinase |
| Vps15 |
PIK3R4/VPS15 |
Ser/Thr protein kinase |
| Vps30/Atg6 |
BECN1 |
Component of PtdIns3K complex I and II |
Atg14
|
ATG14
|
Component of PtdIns3K complex I
|
Atg8 Ubl conjugation system
|
Atg8 |
LC3A/B/C, GABARAP, GABARAPL1/2 |
Ubl, conjugated to PE |
| Atg7 |
ATG7 |
E1-like enzyme |
| Atg3 |
ATG3 |
E2-like enzyme |
Atg4
|
ATG4A/B/C/D
|
Deconjugating enzyme, cysteine proteinase
|
| Atg12 Ubl conjugation system |
Atg12 |
ATG12 |
Ubl |
| Atg7 |
ATG7 |
E1-like enzyme |
| Atg10 |
ATG10 |
E2-like enzyme |
| Atg16 |
ATG16L1 |
Interacts with Atg5 and Atg12 |
| Atg5 |
ATG5 |
Conjugated by Atg12 |
