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. Author manuscript; available in PMC: 2014 Jan 3.
Published in final edited form as: Transfus Clin Biol. 2012 Jun 14;19(3):10.1016/j.tracli.2012.02.003. doi: 10.1016/j.tracli.2012.02.003

Fig. 2.

Fig. 2

Vascular inflammation induced by sCD40L delivered via transfusion. Platelet concentrates used for transfusion can accumulate activated platelets (represented by spiked cells), as well as cleaved and microparticle-bound sCD40L (homo-trimeric protein represented by ovals and ovals attached to circles) over storage time. Four examples of CD40 receptor expressing cells are depicted: PMN (Polymorphonuclear leukocytes), resting platelets, B lymphocytes, and endothelial cells. Some of the downstream effects of CD40 signaling are listed below each cell type.