Table 5.
Comparison of Model Fit and Control Performance across Different Endogenous Glucose Production Models
| Case | Fitting | Control | |||
|---|---|---|---|---|---|
| EGP (mg/kg/min) | Fitting error | Time in band (72 – 144 g/dl) | Hyperglycemic (BG > 180 mg/dl) | Mild hypoglycemic (BG < 72 mg/dl) | Severe hypoglycemic (BG < 47 mg/dl) |
| Suppressed EGP (BG) | 2.77% | EGP too low to sustain modeled BG levels, indicating inability of the EGP model to replicate clinical results. | |||
| 0.3 (5th) | 4.78 % | ||||
| 1.40 (25th) | 3.07 % | ||||
| 2.1 (50th) | 2.58 % | 74.8 % | 8.08 % | 2.25 % | 6 |
| 4.20 | 2.16 % | 77.3 % | 7.10 % | 2.05 % | 3 |
| 4.6 (75th) | 2.11% | 78.0 % | 6.69% | 2.05 % | 3 |
| 5.11a | 2.11 % | 78.4 % | 6.52 % | 2.14 % | 2 |
| 5.50 | 2.10 % | 78.6 % | 6.61 % | 2.10 % | 1 |
| 6.00b | 2.09 % | 79.2 % | 6.35 % | 2.23 % | 1 |
| 6.50 | 2.09 % | 79.5 % | 6.42 % | 2.38 % | 2 |
| 7.00 | 2.08 % | 79.8 % | 6.34 % | 2.56 % | 1 |
| 7.50 | 2.08 % | 79.9 % | 6.17 % | 2.67 % | 1 |
| 7.7 (95th) | 2.08% | 80.7% | 5.86% | 2.60% | 1 |
| EGP (GI(t)) | 2.28% | 73.7 % | 8.24 % | 2.1 % | 8 |
a
Currently in use with EGP = 5.11 mg/kg/min.19
b
Optimum.