Table 1. Power of correctly identifying the disease SNP location using one pedigree.

				All n cases sharing		n-1 cases sharing
				Significant threshold for designation of high-risk		Significant threshold for designation of high-risk
Prevalence	MAF	Penetrance	Attr. risk (%)	<0.00001	<0.001	<0.00001	<0.001
0.50%	0.005	0.5	100	53.6%	52.8%	56.6%	55.9%
		0.2	40	30.3%	25.5%	38.9%	33.5%
	0.0005	0.5	10	71.0%*	42.3%	86.2%*	51.2%
		0.2	4	48.5%	17.5%	65.9%	23.3%
	0.00005	0.5	1	30.8%	10.2%	37.3%	11.5%
		0.2	0.4	32.4%*	6.2%	42.5%*	6.7%
1%	0.005	0.5	50	68.9%	54.2%*	85.2%	68.0%*
		0.2	20	24.2%	19.7%	33.2%	25.7%
	0.0005	0.5	5	32.3%	18.2%	42.6%	24.1%
		0.2	2	39.8%	9.2%	62.5%	11.8%
	0.00005	0.5	0.5	35.2%	7.8%	47.2%	9.1%
		0.2	0.2	12.6%	5.4%	17.6%	5.6%

Note: MAF, minor allele frequency. The number of cases (n) in a pedigree varied based on the genetic model and the high-risk threshold. For models with a prevalence of 1% the average number of cases was 8.2 and 9.7 for the high-risk thresholds of p<0.001, and p<0.00001, respectively. For models with a prevalence of 0.5% the average number of cases was 4.0 and 6.2 for the high-risk thresholds of p<0.001, and p<0.00001, respectively.

^*indicates a scenario also investigated by classical multipoint linkage analysis for comparison.