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. 2014 Jan 15;141(2):389–398. doi: 10.1242/dev.099119

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — FGF overexpression supresses cerebellar cell fates. (A-C) Electroporation of Fgf8b + gfp at E3 (arrow) disrupts Lhx9 at E6, producing both ectopic expression (arrowheads) and gaps (arrows). (D,E) Electroporation of gfp (D) or Fgf8b + gfp (E) at E4 produces markedly different numbers of GFP-labelled cells. (F) Electroporation of Fgf8b + gfp at E3 cell-non-autonomously induces at E5 ectopic proliferation (PH3 in red). (G) Electroporation of Atoh1-cre + stop-gfp into rl at E3 (arrow) labels rhombic lip derivatives at E7. (H,I) Co-electroporated Fgf8b increases the proportion of ventral derivatives (H) and downregulates the deep cerebellar nucleus marker Tbr1 (I). Scale bars: 200 μm (D,E,G,H); 100 μm (F, left and middle); 50 μm (F, right). rl, rhombic lip.