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. Author manuscript; available in PMC: 2014 Jan 3.
Published in final edited form as: Curr Opin Cell Biol. 2012 Aug 28;24(5):10.1016/j.ceb.2012.07.006. doi: 10.1016/j.ceb.2012.07.006

Figure 1.

Figure 1

Classes of intracellular adhesome proteins in general (A); in cadherin adhesion (B); and integrin adhesion (C). The proteins are divided in classes depending on their overlap in phenotype and colocalization with the adhesion receptor. Class 1, 2A-B and 2C proteins colocalize with receptor in all cases, and loss of class 1 proteins shares all phenotypes with the loss of receptor, loss of class 2A-B shares some phenotypes, and loss of class 2C does not share any. Class 3A and 3C proteins colocalize with receptor in some cases, and loss of class 3A proteins results in some common phenotypes with loss of receptor, while loss of class 3C proteins does not. We include a class 4 of proteins that do not colocalize with receptor, and loss of these proteins results in all or some phenotypes caused by loss of receptor. * indicates that the class of the protein was predicted based on indirect data or data from other model systems. For detailed description of the proteins and references to literature see Tables 2 and 3.