Table 2.
Influence of patient, lesion and biopsy variables on likelihood of obtaining diagnostic tissue sufficient for biomarker analyses: Univariate analysis
| Characteristic | Number of Biopsies, (n) | Diagnostic n, (%) | Non-Diagnostic n, (%) | P-value |
|---|---|---|---|---|
|
| ||||
| Size | 0.5842 | |||
| <2 cm | 11 | 8 (72.7) | 3 (27.3) | |
| 2–5 cm | 135 | 112 (82.9) | 23 (17.1) | |
| >5 cm | 24 | 21 (87.5) | 3 (12.5) | |
|
| ||||
| Lesion Biopsied | 0.0042 | |||
| Primary Tumor | 113 | 87 (77) | 26 (23) | |
| Metastatic Focus | 57 | 54 (94.7) | 3 (5.3) | |
|
| ||||
| History of Prior Radiation Therapy to the Lesion Biopsied | 0.5820 | |||
| Yes | 28 | 22 (78.6) | 6 (21.4) | |
| No | 142 | 119 (83.8) | 23 (16.2) | |
|
| ||||
| Lesion Morphology | 0.0315 | |||
| Mass/Nodule | 153 | 130 (84.9) | 23 (15.1) | |
| Consolidation | 9 | 7 (77.8) | 2 (22.2) | |
| Cavitation | 8 | 4 (50) | 4 (50) | |
|
| ||||
| Lesion Location | 0.1969 | |||
| Lung | 150 | 123 (82) | 27 (18) | |
| Hilum/Mediastinum | 8 | 6 (75) | 2 (25) | |
| Pleura | 12 | 12 (100) | 0 (0) | |
|
| ||||
| Lesion Depth | 0.1763 | |||
| 0–2 cm | 82 | 72 (87.8) | 10 (12.2) | |
| 2–4 cm | 66 | 53 (80.3) | 13 (19.7) | |
| >4 cm | 22 | 16 (72.7) | 6 (27.3) | |
|
| ||||
| Tumor Histology | 0.3427 | |||
| NSCLC-NOS | 31 | 28 (90.3) | 3 (9.7) | |
| NSCLC-SCC | 26 | 20 (76.9) | 6 (23.1) | |
| NSCLC-Adenocarcinoma | 103 | 86 (83.5) | 17 (16.5) | |
| Other | 10 | 7 (70) | 3 (30) | |
|
| ||||
| PET-CT within 6 months | 0.5391 | |||
| Yes | 76 | 65 (85.5) | 11 (14.5) | |
| No | 94 | 76 (80.8) | 18 (19.2) | |
NSCLC-non-small cell lung cancer; SCC-squamous cell carcinoma; NOS-not otherwise specified