Table 1.
Fetal Arterial Blood Gases and Metabolic Status.a
| Experimental Group | Baseline | At Start Infusion | After End of Infusion | +48 hours Post | |
|---|---|---|---|---|---|
| pHa | I/R vehicle | 7.36 ± 0.01 | 7.11 ± 0.03b | 6.97 ± 0.03b | 7.34 ± 0.01 |
| I/R allopurinol | 7.36 ± 0.01 | 7.07 ± 0.02b | 6.97 ± 0.03b | 7.35 ± 0.01 | |
| ABE, mEq/L | I/R vehicle | 4.8 ± 0.5 | −6.7 ± 2.1b | −15.0 ± 1.7b | 3.0 ± 0.8 |
| I/R allopurinol | 3.6 ± 0.8 | −9.0 ± 0.98b | −15.0 ± 1.3b | 2.8 ± 0.5 | |
| PaO2, mm Hg | I/R vehicle | 21.3 ± 2.0 | 14.2 ± 1.9b | 14.0 ± 1.4b | 23.8 ± 2.0 |
| I/R allopurinol | 20.8 ± 1.9 | 13.6 ± 2.4b | 13.4 ± 3.7b | 21.4 ± 1.3 | |
| PaCO2, mm Hg | I/R vehicle | 58.0 ± 1.2 | 81.7 ± 3.4b | 90.8 ± 5.5b | 57.0 ± 0.91 |
| I/R allopurinol | 55.2 ± 2.0 | 84.4 ± 5.4b | 90.6 ± 5.4b | 54.8 ± 1.2 | |
| SatHb, % | I/R vehicle | 55.3 ± 5.0 | 24.0 ± 3.4b | 21.8 ± 2.1b | 58.8 ± 5.7 |
| I/R allopurinol | 57.9 ± 7.4 | 24.6 ± 5.0b | 22.8 ± 5.9b | 58.1 ± 5.5 | |
| Lactate, mmol/L | I/R vehicle | 1.13 ± 0.20 | 6.11 ± 1.17b | 9.79 ± 1.24b | 0.92 ± 0.14 |
| I/R allopurinol | 1.05 ± 0.20 | 6.09 ± 0.94b | 9.09 ± 0.99b | 1.19 ± 0.27 | |
| Glucose, mmol/L | I/R vehicle | 0.97 ± 0.09 | 1.66 ± 0.29b | 1.72 ± 0.10b | 1.04 ± 0.16 |
| I/R allopurinol | 0.80 ± 0.11 | 1.65 ± 0.38b | 1.18 ± 0.30b | 1.05 ± 0.23 |
Abbreviations: ABE, acid/base excess; I/R, ischemia–reperfusion; SatHb, saturation of hemoglobin with oxygen.
a Fetal physiologic parameters (arterial pH, blood gases, glucose, and lactate values) 60 minutes before umbilical cord compression (baseline), immediately before and immediately after the end of infusion of allopurinol or buffered saline, and at 48 hours after the I/R challenge (see Materials and Methods and Figure 1).
b Significant differences within groups are P < .05 versus baseline (2-way repeated measures analysis of variance with post hoc t Newman-Keuls test). There were no significant differences between the 2 treatment groups.