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. Author manuscript; available in PMC: 2014 Sep 17.
Published in final edited form as: Circulation. 2013 Aug 19;128(12):10.1161/CIRCULATIONAHA.113.003072. doi: 10.1161/CIRCULATIONAHA.113.003072

Figure 1.

Figure 1

Mice exposed to S. mansoni eggs develop PH and vascular remodeling. (A) Mice IP sensitized to S. mansoni eggs followed by IV augmentation have an increase in RVSP (mean ± SE; n = 5–6 mice per group; rank-sum test ****P < 0.001; this experiment was repeated 3 times with similar results). (B) Representative H&E and immunofluorescence staining for α-smooth muscle actin (α-SMA) and thrombomodulin of unexposed and IP/IV egg exposed mouse lungs (Scale bars: 50µm). (C and D) Quantitative fractional thickness of the pulmonary vascular media and intima in unexposed and IP/IV egg-exposed mice (mean ± SE; n = 5–6 mice per group; rank-sum test **P < 0.01; P=0.66 for intima thickness). (E) Fulton index (RV/(LV+S)) of unexposed and IP/IV egg exposed mice (mean ± SE; n = 5–6 mice per group; rank-sum test P = 0.052).