Skip to main content
. Author manuscript; available in PMC: 2014 Sep 17.
Published in final edited form as: Circulation. 2013 Aug 19;128(12):10.1161/CIRCULATIONAHA.113.003072. doi: 10.1161/CIRCULATIONAHA.113.003072

Figure 3.

Figure 3

The Rho kinase inhibitor fasudil acutely decreases but does not normalize the RVSP in IP/IV S. mansoni egg-exposed mice. (A) GTP-bound (active) RhoA concentration in unexposed and egg exposed mice (mean ± SE; n = 4 mice per group; rank-sum test *P < 0.05). (B) Representative plots of the effect of fasudil on RVSP in unexposed and egg exposed mice (N=1 per group), administered at time = 0. (C and D) RVSP in unexposed and IP/IV egg exposed mice 5 minutes after fasudil administration, and the decrease in pressure with fasudil treatment (mean ± SE; n = 5–6 mice per group; rank-sum test P = 0.052 for post-fasudil; ***P < 0.005). (E and F) Quantitative fractional thickness of the pulmonary vascular media and intima in unexposed and egg exposed mice after fasudil administration (mean ± SE; n = 5–6 mice per group; rank-sum test ***P < 0.005).