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. Author manuscript; available in PMC: 2014 Sep 17.
Published in final edited form as: Circulation. 2013 Aug 19;128(12):10.1161/CIRCULATIONAHA.113.003072. doi: 10.1161/CIRCULATIONAHA.113.003072

Figure 7.

Figure 7

Treatment with the pan-TGF-β neutralizing antibody 1D11 prevents the increase in pressure from IP/IV S. mansoni egg exposure. (A) RVSP in mice treated with 1D11 or IgG control, and unexposed or exposed to eggs (mean ± SE; n = 3–6 mice per group; ANOVA on ranks P=0.001; *P < 0.05; by post-hoc Dunn’s test). (B) Quantitative fractional thickness of the pulmonary vascular media in mice treated with 1D11 or IgG control, and unexposed or egg exposed (mean ± SE; n = 3–6 mice per group; ANOVA on ranks P=0.002; *P < 0.05 by post-hoc Dunn’s test). (C–F) IL4 and IL13 RNA and protein quantity as measured by RNA-seq and ELISA in mice treated with 1D11, IgG, or no treatment (NT), unexposed or IP/IV exposed to S. mansoni eggs (RPKM: reads per kilobase of exon model per million mapped reads; mean ± SE; n = 3–5 mice per group; ANOVA on ranks P=0.008 for IL4 RNA data, P=0.025 for IL4 protein data, P=0.010 for IL13 RNA data, P=0.027 for IL13 protein data; *P<0.05 by post-hoc Dunn’s test).