Figure 3.

Overview of Propionibacterium freudenreichii metabolism of in the colonic environment compared to spent medium. Differential comparisons between groups were performed gene by gene using a modified t-test. Genes were declared as differentially expressed with P value ≤ 0.001 and |fold change| > 2. In blue, genes repressed in the colonic environment: glycolysis, tricarboxylic acid cycle (TCA), Wood-Werkman cycle, oxidative phosphorylation. In red, gene induced or stably expressed in the colonic environment compared to spent medium: pentose phosphate, gluconate, inositol, propanediol, uracil and branched-chain amino-acid degradation.