The Hofer and Frahm scheme illustrating the topography of the midsagittal corpus callosum. The regions of interest (ROIs) were computed in each region bilaterally. Region I corresponds to the genu and region V corresponds to the splenium, whereas regions II–IV correspond to the truncus. The fibers from the different regions project to the following regions of the brain: region I, prefrontal; region II, premotor and supplementary motor; region III, motor; region IV, sensory; region V, posterior parietal, temporal, and occipital. A, anterior. P, posterior. Redrawn from Hofer and Frahm21; reproduced with permission from the publisher and author.