Table 1.
SERPIN aliases and function
| Clade name | Clade | Serpin gene name | Known aliases | Biological function | References |
|---|---|---|---|---|---|
| Alpha 1 proteinase inhibitor antitrypsin |
A |
SERPINA1 |
Alpha 1PI |
Inflammation, complement activation, apoptosis |
17 |
|
SERPINA2 |
|
|
|
||
|
SERPINA3 |
Alpha1 ACT |
Apoptosis, Alzheimer’s disease, prohormone conversion, inflammation and complement activation |
3,16 |
||
|
SERPINA4 |
PI4, KST, KAL |
Kidney function, inflammation, and complement activation |
18 |
||
|
SERPINA5 |
PCI |
Coagulation, inflammation, complement activation, sperm development |
|
||
|
SERPINA6 |
CBG |
Hormone transport |
16 |
||
|
SERPINA7 |
TBG |
Hormone transport |
|
||
|
AGT |
SERPINA8 |
Blood pressure regulation, renal development |
19 |
||
|
SERPINA9 |
Centurin |
B cell development |
3 |
||
|
SERPINA10 |
PZI |
Inhibition of activated factors Z and XI |
3 |
||
|
SERPINA11 |
|
|
|
||
|
SERPINA12 |
Vaspin |
Inhibits kallikrein; unknown role in insulin sensitivity |
20,21 |
||
|
SERPINA13P |
|
|
|
||
|
SERPINB1 |
PI2, LEI, MNEI, EI |
Inflammation, complement activation |
3 |
||
|
SERPINB2 |
PAI2, placental PAI, monocyte ARG serpin, PLANH2 |
Fibrinolysis, elastase inhibitor |
3 |
||
| ov Serpins |
B |
SERPINB3 |
SCCA1, SCC |
Inhibition of cathepsins, tumor promotion |
32 |
|
SERPINB4 |
SCCA2, PI11 |
Inhibition of cathepsins and chymase |
33 |
||
|
SERPINB5 |
Maspin, PI5 |
Tumor cell invasion, angiogenesis |
3 |
||
|
SERPINB6 |
DFNB91, PI6, CAP |
Cathepsin inhibitor |
34 |
||
|
SERPINB7 |
Megsin |
Renal development, mesangial cell proliferation |
35 |
||
|
SERPINB8 |
PI8, CAP2 |
Uncharacterized |
3 |
||
|
SERPINB8P1 |
|
|
|
||
|
SERPINB9 |
PI9, CAP3 |
|
|
||
|
SERPINB10 |
PI10, BOMAPIN |
Hematapoetic and myeloid development |
35 |
||
|
SERPINB11 |
EPIPIN |
Uncharacterized |
36 |
||
|
SERPINB12 |
YUKOPIN |
Trypsin inhibition |
37 |
||
|
SERPINB13 |
PI13, headpin, HUR7, hurpin |
|
|
||
| Antithrombin |
C |
SERPINC1 |
AT3, ATIII, antithrombin3 |
Coagulation, angiogenesis |
38 |
| Heparin cofactor |
D |
SERPIND1 |
HCFII, HCF2, heparin cofactor II, HLS2 |
Coagulation |
40 |
| Nexin/plasminogen activator inhibitor 1 |
E |
SERPINE1 |
PAI, PLANH1 |
Angiogenesis, fibrinolysis |
3 |
|
SERPINE2 |
PI7, GDN, ‘glial-derived nexin 1,’ nexin, PN1, PNI |
Neurotrophic factor |
41 |
||
|
SERPINE3 |
|
|
|
||
| Alpha 2 antiplasmin pigment epithelium derived factor |
F |
SERPINF1 |
PEDF |
Neurotrophic factor, angiogenesis |
16 |
|
SERPINF2 |
Alpha 2AP, PLI, A2AP, AAP, ‘alpha-2-antiplasmin,’ ALPHA‒2‒PI, ‘alpha‒2‒plasmin inhibitor,’ API |
Fibrinolysis |
3 |
||
| C1 inhibitor |
G |
SERPING1 |
C1NH,C1–INH, C1IN, HAE1, HAE2, ‘plasma protease C1 inhibitor’ |
Microbial infection |
42 |
| Heat shock protein |
H |
SERPINH1 |
CBP1, CBP2, collagen, HSP47 |
Chaperone |
43 |
| Neuroserpin |
I |
SERPINI1 |
Neuroserpin, PI12 |
Neurotrophic factor |
46 |
| SERPINI2 | Pancpin, PI14, TSA2004, MEPI | Tumor cell invasion | 47 |
SERPINS are divided into clades and gene name with known aliases and biological function are provided. Alternative name information was determined using HGNC (http://www.genenames.org) and/or MGI (http://www.informatics.jax.org).