Table 6.
Cycle and Dose Information by Genotype for each Dose Level*
| Genotype | Dose Level |
N | Median (Range) | |||
|---|---|---|---|---|---|---|
| Treatment Cycles |
OXAL Dose given (mg/m2) |
IRI Dose given (mg/m2) |
CAP Dose given (mg/m2) |
|||
| UGT1A1 (*28/*28) |
−2 | 6 | 3 (1,9) | 158 (146, 170) | 139 (125, 150) | 9100 (4833, 9100) |
| −1 | 3 | 4 (1, 7) | 173 (142, 179) | 161 (142, 203) | 5538 (4000, 8157) | |
| 1 | 2 | 1.5 (1,2) | 153 (151, 154) | 256 (245, 267) | 4750 (2600, 6900) | |
| UGT1A1 (*1/*28) |
1 | 12 | 3.5 (1, 10) |
150 (128, 180) | 264 (225, 320) | 9100 (7700, 13440) |
| 2 | 6 | 4.5 (1, 7) | 161 (139, 205) | 256 (246, 362) | 19786 (16220, 26250) | |
| UGT1A1 (*1/*1) |
2 | 3 | 6 (1, 8) | 153 (126, 180) | 236 (222, 318) | 13094 (13083, 20450) |
| 3 | 3 | 4 (4, 5) | 215 (187, 230) | 258 (173, 288) | 17588 (10838, 21000) | |
| 4 | 12 | 3 (1, 20) | 243 (177, 307) | 261 (177, 383) | 33038 (7600, 95161) | |
| 5 | 3 | 2 (1, 2) | 229 (195, 233) | 334 (317, 340) | 21000 (9850, 39200) | |
*
Calculated by computing the median dose of the mean total dose for each patient across all cycles for all patients treated at a given dose level.