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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Trends Neurosci. 2013 Jan 18;36(2):10.1016/j.tins.2013.01.003. doi: 10.1016/j.tins.2013.01.003

Table 1.

Summary of CNS 5-HT receptor and 5-HT transporter (5-HTT) PET and SPECT studies in AN in the ill and recovered state compared to healthy controlsa

Receptor/
Transporter		 Imaging
Type		 Ill Recovered Regions Direction of
changeb 		Refs
5-HT2A PET n/a AN mesial temporal (amygdala and hippocampus), pre- and subgenual cingulate, occipital/parietal cortical regions − [122]
n/a AN-BN left subgenual cingulate, left parietal cortex, right occipital cortical regions − [123]
AN, AN-BN n/a n/a = [124]
SPECT AN n/a left frontal, bilateral parietal, occipital cortical regions − [125]
5-HT1A PET n/a AN n/a = [126]
n/a AN-BN cingulate, lateral and mesial temporal, lateral and medial orbital frontal, parietal, and prefrontal cortical regions; dorsal raphe + [126]
AN, AN-BN n/a cingulate, lateral and mesial temporal, lateral and medial orbital frontal, parietal, and prefrontal cortical regions; dorsal raphe + [124]
n/a AN Right superior temporal, inferior frontal gyrus; parietal operculum, temporoparietal junction; left amygdala, parahippocampal gyrus, left temporal pole + [117]
AN n/a Right superior temporal, inferior frontal gyrus; parietal operculum, temporoparietal junction; left amygdala, parahippocampal gyrus, left temporal pole = [117]
5-HTT PEt n/a AN n/a = [57]
n/a AN-BN n/a = [57]
a

Abbreviations: AN, restricting-type AN; AN-BN, bulimic type AN.

b

+, increased compared to healthy controls; −, decreased compared to healthy controls; =, normal.