Table 3.
Hazard ratios (HR) of mortality in 1024 patients on ART
|
Determinants |
Univariate analysis |
Multivariate analysis
f
|
||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
|
Place of ART
a
|
|
|
|
|
| Kailali Distric
b
(ref.) |
1.00 |
|
|
|
| Kanchanpur District
b
|
2.03 (1.10 – 3.73) |
0.023 |
|
|
| Doti District
c
|
1.93 (1.24 – 3.00) |
0.004 |
|
|
| Achham District
c
|
1.71 (1.05 – 2.78) |
0.031 |
|
|
|
Sex |
|
|
|
|
| Female (ref.) |
1.00 |
|
1.00 |
|
| Male |
5.40 (3.37 – 8.65) |
<0.001 |
4.55 (2.43 – 8.51) |
<0.001 |
|
Age groups (years) |
|
|
|
|
| 15- 32 years (ref.) |
1.00 |
|
|
|
| 33- 40 years |
1.66 (1.04 – 2.64) |
0.033 |
|
|
| >40 years |
1.93 (1.19 – 3.14) |
0.008 |
|
|
|
Education |
|
|
|
|
| Illiterate (ref.) |
1.00 |
|
|
|
| Literate |
1.45 (0.96 – 2.17) |
0.075 |
|
|
|
Performance scale |
|
|
|
|
| Normal (ref.) |
1.00 |
|
1.00 |
|
| Bedridden <50% |
4.54 (2.99 – 6.88) |
<0.001 |
2.05 (1.19 – 3.52) |
0.010 |
| Bedridden >50% |
5.53 (3.45 – 8.87) |
<0.001 |
3.41 (1.67 – 6.98) |
0.001 |
|
Bodyweight (Kg)d |
1.02(1.01 – 1.05)
g
|
0.048 |
1.04(1.01 – 1.07)
g
|
0.010 |
|
WHO clinical stage |
|
|
|
|
| Stage I or II (ref.) |
1.00 |
|
1.00 |
|
| Stage III |
4.39 (2.25- 8.55) |
<0.001 |
2.96 (1.31- 6.69) |
0.009 |
| Stage IV |
8.85 (4.43-17.66) |
<0.001 |
3.28 (1.30- 8.29) |
0.012 |
|
CD4 count (cells/mm
3
)d |
0.99 (0.98- 0.99) |
<0.001 |
|
|
|
Drug toxicity/side effects |
|
|
|
|
| No (ref.) |
1.00 |
|
|
|
| Yes |
1.45 (0.96- 2.19) |
0.078 |
|
|
|
Active TB during treatment |
|
|
|
|
| No (ref.) |
1.00 |
|
|
|
| Yes |
1.73 (1.15- 2.61) |
0.009 |
|
|
|
ART regimen
e
|
|
|
|
|
| d4T/3TC/NVP (ref.) |
1.00 |
|
|
|
| d4T/3TC/EFV |
0.90 (0.39- 2.07) |
0.803 |
|
|
| ZDV/3TC/NVP |
0.49 (0.31- 0.77) |
0.002 |
|
|
| ZDV/3TC/EFV |
0.97 (0.54- 1.73) |
0.907 |
|
|
|
ART regimen change |
|
|
|
|
| No (ref.) |
1.00 |
|
|
|
| Yes | 1.37 (0.94- 2.00) | 0.10 | ||
a Kailali District (Seti Zonal Hospital and Tikapur Hospital), Kanchanpur District (Kanchanpur Zonal Hospital), Doti District (Doti District Hospital), and Achham District (Achham District Hospital). bplain/terai district, chill district . dContinuous variables. e TDF/3TC/EFV regimen was not included. fCox proportional hazards model adjusted for all variables in the table. gHR for 1 kg decrease in bodyweight.
ref.: reference group.