Table 2.
Run parameters and responses for three-level three-factorial Box–Behnken experimental design
| Runs order | D/P | W/O | PVA (%) | Size (nm) | EE (%) | DL (%) | Drug release in 1 hr | Drug release in 8 hrs |
|---|---|---|---|---|---|---|---|---|
|
1 |
1 |
0 |
-1 |
291 |
35 |
6.3 |
70 |
72 |
|
2 |
0 |
0 |
0 |
241 |
43 |
5.3 |
62 |
68 |
|
3 |
-1 |
0 |
1 |
316 |
51 |
3.2 |
30 |
39 |
|
4 |
1 |
0 |
1 |
259 |
28 |
5.1 |
79 |
79 |
|
5 |
0 |
-1 |
-1 |
259 |
26 |
3.1 |
75 |
80 |
|
6 |
0 |
0 |
0 |
279 |
47 |
5.8 |
49 |
50 |
|
7 |
0 |
-1 |
1 |
260 |
16 |
2 |
80 |
92 |
|
8 |
0 |
1 |
-1 |
304 |
32 |
4 |
51 |
59 |
|
9 |
0 |
1 |
1 |
311 |
32 |
4.1 |
36 |
43 |
|
10 |
-1 |
1 |
0 |
301 |
49 |
2.4 |
54 |
62 |
|
11 |
1 |
-1 |
0 |
246 |
14 |
2.5 |
92 |
93 |
|
12 |
1 |
1 |
0 |
261 |
26 |
4.8 |
79 |
81 |
|
13 |
0 |
0 |
0 |
268 |
45 |
5.5 |
77 |
86 |
|
14 |
-1 |
0 |
-1 |
303 |
62 |
3 |
29 |
40 |
|
15 |
0 |
0 |
0 |
260 |
45 |
5.6 |
49 |
65 |
|
16 |
-1 |
-1 |
0 |
278 |
41 |
2 |
61 |
75 |
| 17 | 0 | 0 | 0 | 240 | 46 | 5.6 | 50 | 64 |