Table 2.
Clinicopathological data of patients who underwent major hepatectomy for HCC (n=539) according to country of origin
| Variable | France (n=137) | USA (n=111) | China (n=291) | P a |
|---|---|---|---|---|
| Male gender (%) | 80 | 59 | 84 | <0.0001 |
| Age (years), median (range) | 57 (15–85) | 64 (9–87) | 51 (13–82) | <0.0001 |
| AFP (ng/dL), median (range) | 191 (1–700,000) | 25 (0–249,417) | 354 (2–1,300,000) | <0.0001 |
| Child–Pugh class B (%) | 4 | 0 | 2 | 0.146 |
| Tumor size (cm), median (range) | 10 (1–24) | 10 (2.4–24) | 9.5 (1–27) | 0.050 |
| Tumor size >5 cm (%) | 82 | 86 | 78 | 0.180 |
| Bilateral lesions (%) | 19 | 34 | 19 | 0.004 |
| Multiple lesions (%) | 39 | 33 | 34 | 0.520 |
| Major vascular invasion (%) | 16 | 10 | 10 | 0.145 |
| Microvascular invasion (%) | 68 | 52 | 60 | 0.048 |
| Fibrosis/cirrhosis (%) | 34 | 7 | 46 | <0.0001 |
| Nodal metastases (%) | 2 | 5 | 0 | 0.002 |
| Extrahepatic metastases (%) | 0 | 1 | 2 | 0.196 |
| Other organ invasion (%) | 10 | 4 | 10 | 0.112 |
| Positive surgical margins (%) | 11 | 7 | 14 | 0.297 |
| Edmondson–Steiner grade (%) | <0.0001 | |||
| 1 | 5 | 19 | 14 | |
| 2 | 37 | 45 | 35 | |
| 3 | 46 | 36 | 43 | |
| 4 | 12 | 0 | 8 | |
| Extended hepatectomy (%) | 28 | 43 | 42 | 0.012 |
| 90-Day mortality (%) | 3 | 2 | 5 | 0.237 |
AFP α-fetoprotein
a
France versus USA versus China