Table 2. ABE/SILAM data for proteins identified by prior work to be likely HIP14 palmitoylation substrates.

(Huang et al., 2009; Huang et al., 2004; Ohyama et al., 2007).

Gene Symbol	Description	Hip14-gt Change	YAC128 Change
Dnajc5	Cysteine string protein (CSP); may be involved in Ca2+-dependent neurotransmitter release	−8%***	−7% (ns)
Syt1	Synaptotagmin 1; synaptic vesicle integral membrane protein; may be Ca2+ sensor for vesicle release.	−6%***	−1% (ns)
Snap25	SNAP-25; neuronal SNARE protein that acts together with Vamp2 and Stx1 to effect synaptic vesicle release.	−5%*	−7%*
Dlg4	PSD-95; SAP-90; MAGK scaffolding protein that clusters NMDA glutamate receptors at synapse.	−5% (ns)	−13%*
Gad2	GAD-65; glutamate decarboxylase 2; GABA neurotransmitter biosynthesis; tethers to GABA-containing synaptic vesicles.	+2% (ns)	+2% (ns)
Gap43	GAP-43; may play a role in neurite outgrowth and nerve regeneration.	+7% (ns)	+12% (ns)
Htt	Huntingtin; disease protein of HD.	not detected	not detected
Lck	Lymphocyte-specific protein tyrosine kinase	not detected	not detected

The change detected in Hip14-gt brain palmitoyl-proteome relative to WT brain palmitoyl-proteome is reported (Significance levels: * P < 0.05; ** P < 0.01; *** P < 0.001). See Figure S2 for graphical depictions of the peptide-level data for the proteins of this table.