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. Author manuscript; available in PMC: 2014 Oct 18.
Published in final edited form as: Science. 2013 Oct 18;342(6156):10.1126/science.1241224. doi: 10.1126/science.1241224

Fig. 3. Sleep improves clearance of Aβ.

Fig. 3

(A). Time-disappearance curves of 125I-Aβ1-40 after its injection into the frontal cortex in awake (orange triangles), sleeping (green diamonds), and anesthetized (red squares, ketamine/xylazine) mice. (B) Rate constants derived from the clearance curves. (C) Time-disappearance curves of 14C-inulin after its injection into the frontal cortex of awake (orange triangles), sleeping (green diamonds), and anesthetized (red squares, ketamine/xylazine) mice. (D) Rate constants derived from the clearance curves. A total of 77 mice were included in the analysis: 25 awake, 29 asleep, and 23 anesthetized, with 3 to 6 mice per time point. *P < 0.05 compared with awake, ANOVA with Bonferroni test.