Table 4.

Correlation among phosphorylated (p) AKT expression, clinical benefit and changes in receptor protein kinase expression

Correlation of change in pAKT expression with	Pearson’s correlation coefficient	P-value
Clinical response (PR)	−0.45	0.23
Clinical benefit (PR + SD)	−0.37	0.32
Change in C-KIT expression	0.31	0.42
Change in PDGFR-α expression	0.37	0.33
Change in PDGFR-β expression	0.21	0.59

Changes in protein expression were categorized as follows: −1, decrease; 0, no change; +1, increase. For clinical response, partial response (PR) was coded as 1 and others as 0. For clinical benefit, PR or stable disease (SD) was coded as 1 and others as 0.