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. 2014 Jan 3;9(1):e81126. doi: 10.1371/journal.pone.0081126

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© 2014 Banda et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

MCF10AT1 cells, wild type or transduced with either LacZ or GRM1, were implanted into both flanks of athymic nude mice and allowed to grow for 8 weeks, after which MCF10AT1 lesions were harvested. A. Representative wild type MCF10AT1 lesion with both papillary enfolding (green arrow) and cribiform foci (red arrow). B. LacZ control MCF10AT1 lesion. The morphology indicates a hyperplastic lesion with both papillary (green arrow) and initial cribiforming present (red arrow). C. mGluR1-overexpressing MCF10AT1 lesion. The morphology indicates invasive cancer. These figures (A through C) are representative of 10 lesions analyzed for each group (magnification: 100×). D. GRM1 overexpression results in malignant transformation of MCF10AT1 cells. Standard H&E sections of tumors were examined by a trained observer blinded to experimental group, and MCF10AT1 xenografts assessed for the presence and number of foci of carcinoma.