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. 2014 Jan 3;9(1):e82222. doi: 10.1371/journal.pone.0082222

Table 4. Relative incidence estimates for the association between infections, influenza A(H1N1)pdm09 vaccination, seasonal influenza vaccination and Guillain-Barré syndrome.

DK FI FR NL NO SE UK Pooled
RI 95% CI RI 95% CI RI 95% CI RI 95% CI RI 95% CI RI 95% CI RI 95% CI RI 95% CI
Covariates
ILI NA NA NA 10.5 3.0–36.3 30.6 8.6–108 NA 1.8 0.2–16.0 10.4 2.6–41.1
URTI NA NA NA 13.0 4.3–39.2 17.7 6.2–34.7 NA 2.2 0.4–10.6 8.51 3.0–24.0
GI NA NA NA 11.6 2.8–49.4 53.31 6.56–433 NA 2.3 0.2–22.6 11.9 2.5–55.6
Seasonal influenza vaccination NA NA NA 1.2 0.4–4.0 5.5 1.6–18.9 NA 6.0 1.8–19.7 3.9 1.8–8.3
Any influenza A(H1N1)pdm09 vaccination
Unadjusted 7.7 1.1–54.4 1.6 0.5–5.4 6.4 1.0–40.4 2.7 1.3–5.9 3.9 1.6–9.3 4.8 2.1–11.1 3.3 0.3–36.5 3.5 2.2–5.5
Adjusted for calendar month 3.9 0.5–32.2 1.6 0.5–5.4 2.9 0.4–19.6 1.4 0.6–3.4 1.9 0.7–5.2 2.7 1.0–7.8 2.3 0.2–27.7 2.0 1.2–3.1
Adjustment effect any influenza A(H1N1)pdm09 vaccination in NL, NO, UK
Adjusted for calendar month only 1.4 0.6–3.4 1.9 0.7–5.2 2.3 0.2–27.7 1.7 0.8–3.4
Fully adjusted (month, ILI/URTI, GI) 1.2 0.5–3.3 1.5 0.5–4.6 1.5 0.1–23.1 1.4 0.7–2.8
Sensitivity analysis on influenza A(H1N1)pdm09 vaccination for contra-indication
Pseudolikelihood
1st dose 3.6 0.4–29.5 3.2 0.7–14.6 0.6 0.1–6.7 1.3 0.4–4.0 1.6 0.6–4.3 2.4 0.8–6.9 4.8 0.3–83.9 1.9 1.1–3.2
2nd dose NA NA 2.2 0.2–26.3 1.2 0.4–3.4 NA NA NA 1.3 0.5–3.4
Vaccinated cases only NE 2.6 0.2–32.5 NE 1.2 0.2–8.3 1.6 0.3–7.9 2.5 0.4–16.0 NE 1.8 0.7–4.7

Abbreviations: NA: not available or not valid; NE = Not estimable due to small numbers or absence RI: relative incidence; ILI: influenza like illness; URTI: upper respiratory tract infection, GI: gastrointestinal Infection, UK: United Kingdom; NL: Netherlands; FR: France; SE: Sweden; FI: Finland, NO: Norway, DK: Denmark.