Table 3. Summary of finding table for HCC patients with tumor size less than 5.
| Event,% | Effect estimate# | Illustrative comparative risks(95%CI)Ψ | ||||||||||
| Indicators | subgroup | Years | No. of Participants (studies) | RFA | HR | (OR,95% CI) | I2 (%) | P value | NNT or NNH | Assumed risk HR(Control)(Per 1000) | Corresponding risk RFA(Per 1000) | Quality of evidence (GRADE) |
| Overall Survival | All | 1-y | 10621(23) | 96.2 | 96.8 | 0.78[0.63,0.97] | 35 | 0.02* | 166.7† | 941 | 926 (909 to 939) | ⊕⊖ ⊖ ⊖ very low |
| 3-y | 5115(23) | 75.4 | 83.4 | 0.67[0.52,0.85]& | 57 | 0.0008* | 12.5† | 774 | 696 (640 to 744) | ⊕⊖ ⊖ ⊖ very low | ||
| 5-y | 4278(15) | 63.7 | 73.1 | 0.68[0.48,0.97]& | 82 | 0.03* | 10.6† | 731 | 649 (566 to 725) | ⊕⊖ ⊖ ⊖ very low | ||
| Child A | 1-y | 2460(11) | 93.2 | 95.4 | 0.58[0.36,0.94] | 42 | 0.002* | 45.5† | 979 | 964 (950 to 975) | ⊕⊖ ⊖ ⊖ very low | |
| 3-y | 2527(12) | 74.9 | 84.7 | 0.58[0.36,0.94]& | 71 | 0.03* | 10.2† | 844 | 758 (661 to 836) | ⊕⊖ ⊖ ⊖ very low | ||
| 5-y | 2076(7) | 63.1 | 76.7 | 0.59[0.36,0.99]& | 75 | 0.05* | 7.4† | 789 | 688 (574 to 787) | ⊕⊖ ⊖ ⊖ very low | ||
| Recurrence-free survival | All | 1-y | 2388(8) | 75.8 | 79.7 | 0.78[0.64,0.95] | 0 | 0.01* | 25.6† | 782 | 737 (697 to 773) | ⊕⊖ ⊖ ⊖ very low |
| 3-y | 2388(8) | 41.9 | 53.6 | 0.67[0.56,0.79] | 38 | <0.001* | 8.5† | 528 | 428 (385 to 469) | ⊕⊖ ⊖ ⊖ very low | ||
| 5-y | 1845(4) | 27.8 | 41.1 | 0.63[0.40,1.00]& | 73 | 0.05* | 7.5† | 398 | 294 (209 to 398) | ⊕⊖ ⊖ ⊖ very low | ||
| Child A | 1-y | 1922(5) | 75.9 | 79.6 | 0.80[0.64,1.00] | 0 | 0.05* | 27.0† | 763 | 720 (673 to 763) | ⊕⊖ ⊖ ⊖ very low | |
| 3-y | 1922(5) | 43.7 | 54.6 | 0.67[0.56,0.81] | 29 | <0.001* | 9.2† | 548 | 448 (404 to 495) | ⊕⊖ ⊖ ⊖ very low | ||
| 5-y | 1614(3) | 30.2 | 42.2 | 0.64[0.35,1.17]& | 82 | 0.15 | 8.3† | 429 | 325 (208 to 468) | ⊕⊖ ⊖ ⊖ very low | ||
| Disease-free survival | All | 1-y | 2766(12) | 70.1 | 83.9 | 0.46[0.38,0.55] | 46 | <0.001* | 7.2† | 830 | 692 (650 to 729) | ⊕⊕⊖ ⊖ low |
| 3-y | 2698(11) | 37.6 | 57.3 | 0.49[0.34,0.69]& | 67 | <0.001* | 5.1† | 559 | 383 (301 to 467) | ⊕⊖ ⊖ ⊖ very low | ||
| 5-y | 2549(9) | 21.7 | 38.6 | 0.52[0.32,0.84]& | 74 | 0.007* | 5.9† | 286 | 172 (114 to 252) | ⊕⊖ ⊖ ⊖ very low | ||
| Child A | 1-y | 1310(4) | 78.7 | 87.9 | 0.51[0.38,0.69] | 45 | <0.001* | 10.9† | 886 | 799 (747 to 843) | ⊕⊕⊖ ⊖ low | |
| 3-y | 1310(4) | 47.0 | 63.9 | 0.50[0.40,0.63] | 0 | <0.001* | 5.9† | 627 | 457 (402 to 514) | ⊕⊕⊕⊖ Moderate | ||
| 5-y | 1165(2) | 32.5 | 43.4 | 0.62[0.49,0.80] | 4 | 0.0002* | 9.2† | 420 | 310 (262 to 367) | ⊕⊕⊖ ⊖ low | ||
| Recurrence | All | 1-y | 7019(6) | 25.2 | 16.9 | 1.50[1.03,2.19]& | 61 | 0.03* | 12.4† | 171 | 260 (237 to 283) | ⊕⊖ ⊖ ⊖ very low |
| 3-y | 1140(5) | 57.1 | 41.4 | 1.87[1.23,2.84]& | 60 | 0.004* | 6.4† | 406 | 585 (524 to 642) | ⊕⊖ ⊖ ⊖ very low | ||
| 5-y | 945(3) | 75.0 | 58.0 | 2.34[1.76,3.11] | 0 | <0.001* | 5.9† | 590 | 771 (717 to 817) | ⊕⊕⊖ ⊖ low | ||
| Child A | 1-y | 335(3) | 21.5 | 19.0 | 1.18[0.69,2.03] | 0 | 0.54 | 40.0† | 180 | 206 (132 to 308) | ⊕⊖ ⊖ ⊖ very low | |
| 3-y | 335(3) | 50.6 | 46.6 | 1.06[0.38,3.00]& | 81 | 0.91 | 25.0† | 423 | 437 (218 to 687) | ⊕⊖ ⊖ ⊖ very low | ||
| 5-y | 268(2) | 68.6 | 67.2 | 1.04[0.18,6.04]& | 90 | 0.96 | 71.4† | 684 | 692 (280 to 929) | ⊕⊖ ⊖ ⊖ very low | ||
| In-hospital Mortality | — | 3061(14) | 0.1 | 0.3 | 0.47[0.13,1.76] | 0 | 0.26 | 500.0‡ | 0 | 0 (0 to 0) | ⊕⊕⊖ ⊖ low | |
| Complication rate | All | 3073(15) | 8.3 | 17.7 | 0.37[0.29,0.47] | 34 | <0.001* | 10.6‡ | 192 | 81 (64 to 100) | ⊕⊕⊖ ⊖ low | |
| Child A | 1585(5) | 7.7 | 16.7 | 0.35[0.25,0.50] | 0 | <0.001* | 11.1‡ | 314 | 138 (103 to 186) | ⊕⊕⊖ ⊖ low | ||
| Hospital stay | — | 1565(4) | — | — | -6.74[−11.33,−2.14]△ | 98 | 0.004* | - | - | RFA was 6.74 lower (2.14 to11.33) | ⊕⊖ ⊖ ⊖ very low | |
Ψ: The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95%CI);
#, random-effect model; &, fixed-effect model;
△: Mean Difference (IV, Random, 95% CI).
,NNH(Number needed to harm);‡,NNT(Number needed to treat);
*:p<0.05