Table 2. Brain regions exhibiting decreased and increased regional homogeneity among three groups.
Brain region | Brodmann area | Cluster size | MNI | T value | ||||
x | y | z | ||||||
PDD<nD-PD | ||||||||
Left lingual gyrus | 18 | 95 | −18 | −79 | −13 | −3.98 | ||
Left amygdala | 34 | 105 | −20 | −4 | −15 | −3.81 | ||
Right lingual gyrus | 18 | 89 | 13 | −87 | −7 | −3.44 | ||
PDD>nD-PD | ||||||||
Left middle frontal gyrus | 46 | 98 | −36 | 19 | 39 | 4.44 | ||
Right inferior frontal gyrus | 45 | 101 | 49 | 25 | 5 | 3.52 | ||
PDD<NC | ||||||||
Left hippocampus | 20 | 107 | −32 | −20 | −13 | −5.01 | ||
Left pallidum | 103 | −23 | −1 | 0 | −4.26 | |||
Left insula | 48 | 108 | −37 | −14 | 12 | −3.87 | ||
Right precental gyrus | 6 | 111 | 51 | 5 | 45 | −3.81 | ||
Right pallidum | 111 | 19 | 6 | 0 | −3.63 | |||
Right fusiform gyrus | 37 | 97 | 26 | −63 | −11 | −3.61 | ||
Left precental gyrus | 6 | 107 | −48 | −5 | 46 | −3.54 | ||
PDD>NC | ||||||||
Right inferior frontal gyrus | 45 | 98 | 53 | 21 | 2 | 4.20 | ||
Right cerebellum | 109 | 37 | −50 | −45 | 3.09 | |||
nD-PD >NC | ||||||||
left cerebellum | 90 | −19 | −50 | −55 | 3.66 | |||
Right cerebellum | 91 | 20 | −49 | −55 | 3.53 | |||
Right superior frontal gyrus | 8 | 115 | 10 | 27 | 54 | 3.38 |
NC: normal controls, PDD: Parkinson’s disease patients with depression, nD-PD: non-depressed Parkinson’s disease patients. A>B: Compared with B group, A group showed increased ReHo values. A<B: Compared with B group, A group showed decreased ReHo values (P<0.05, AlphaSim corrected).