Table 3. Effects of coexpression with the β1 subunit on the voltage dependence of activation and steady-state inactivation of Nav1.6 sodium channels expressed in HEK293 cells.a .
Activation | Inactivation | |||||
Channel | V0.5 | K | n | V0.5 | K | n |
Nav1.6 | −35.2±0.8 | 4.19±0.17 | 64 | −68.7±0.7 | 6.50±0.10 | 63 |
Nav1.6β1 | −28.6±0.8**b | 4.90±0.12** | 65 | −63.5±0.8* | 6.11±0.08** | 66 |
a Values are means ± SE calculated from fits of the data from the indicated number of individual cells to the Boltzmann equation; V0.5, midpoint potential (mV) for voltage-dependent activation or inactivation; K, slope factor.
b Significantly different from the value for Nav1.6 channels (*P<0.001; **P<0.0005).