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(a) An example of the pre-RT a1 histogram of a brain metastasis with a tumor volume of 17.6 cm3. (b) The pooled PDF (light gray) of the pre-RT a1 (cPDF1) from all the lesions and the three probability membership functions determined by FCM clustering. The cPDF1 is partitioned into three classes: representing low (dotted-dashed black), intermediate (dashed black), and high (solid black) a1 classes. a1: coefficient projection of the DCE curves on the 1st principal component.
