TABLE.

Goals of the National Cancer Institute’s Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation

Protocol Development Goals To establish multicenter networks for basic, translational, epidemiologic, and clinical research Leverage and integrate existing networks, consortia, organizations and agencies Align investigators and institutions with established research interests Promote ongoing research activities To help address key issues Funding Infrastructure Access to new agents Trial design, statistical challenges Central lab monitoring for novel endpoints and biomarkers Data collection and reporting Biorepository Establishment Goals To facilitate the establishment of a network of biorepositories for the collection of samples before and after HSCT to aid in laboratory and clinical studies To promote the collection of human samples Pre- and post- transplant malignant cells Allograft Blood at set time points post-transplant and at relapse To establish standards for collection, storage, utilization and distribution To help coordinate investigators and institutions with established repositories Disease-Specific Response and Relapse Definitions and Monitoring Goals To refine, implement and study proposed definitions for disease-specific response and relapse and for monitoring of MRD To incorporate sensitive evaluation methods into clinical trials Determine clinical relevance of MRD surveillance in specific diseases Assess the impact of interventional strategies after detection of MRD To work towards increased data collection, standardization and reporting specifically related to relapse after HSCT

HSCT: hematopoietic stem cell transplantation; MRD: minimal residual disease