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. 2013 Nov 1;3(11):e156. doi: 10.1038/bcj.2013.53

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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cMYC/KRAS12V-induced plasmacytoma in BALB/c mice. (a) Recipients receiving MIG- or cMYC- or KRAS12V-transfected donor cells remained tumor free, whereas all recipients of cMYC/KRAS12V cells died with plasmacytomas. Secondary transplantation recipients of cMYC/KRAS12V-transduced tumor cells died with similar syndromes (2nd, secondary transplantation). Primary transplantation was repeated five times, and secondary transplantation was independently and repeatedly performed. Group sizes and survival times are indicated. (b) Tumor in peritoneal cavity and splenomegaly were observed in the cMYC/KRAS12V group animals (n=20, from five independent experiments). (c) H&E staining showing tumor cell morphology (n=6). (d) Tumor cells from peritoneal cavity (P.C.) and ascites (A.C.) (n=10) were characterized as CD138⁺B220⁻IgM⁻GFP⁺ by flow cytometry.