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. 2013 Nov 1;3(11):e156. doi: 10.1038/bcj.2013.53

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Renal and bone alterations in cMYC/KRAS12V-induced plasmacytoma mice. (a) Renal tissue from mice receiving MIG-, cMYC-, KRAS12V- and cMYC/KRAS12V-transfected cells (n=3 each group) were analyzed by light microscopy (hematoxylin-eosin staining) and IHC staining with antibodies against mouse Ig κ chains. (b) Histological sections of kidneys of mice receiving cMYC/KRAS12V-transduced plasmacytomas were analyzed by IHC staining with antibodies against mouse Ig κ and λ light chains, as well as IgG and IgM heavy chains. (c) Micro-CT analysis demonstrated no bone lesions in all the group animals. Representative graphs from three individual animals are shown.