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. 2013 Dec 30;9:68. doi: 10.1186/1744-8069-9-68

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Copyright © 2013 Simonic-Kocijan et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The time course of head withdrawal thresholds following injection of CFA and saline into the masseter muscle. Unilateral injection of CFA into the masseter muscle induces allodynia in ipsilateral masseter at 4 h, day 1, day 4 and day 7 after injection. (A) Head withdrawal thresholds for the ipsilateral masseter (two-way ANOVA followed by Bonferroni post-hoc, n = 6). Allodynia of contralateral masseter was observed at time point of day 1and day 4. (B) Contralateral masseter (two-way ANOVA followed by Bonferroni post hoc, n = 6). Results are presented as means ± s.e.m. *p < 0.05; ** p < 0.01;*** p < 0.001 versus saline group at same time point. Note the lowest head withdrawal thresholds at bilateral masseter muscle 4 days after CFA injection.