Table 1.
In vitro activities of tested antimicrobial agents against 36 tigecycline non-susecptible K. pneumoniae isolates
| Antimicrobial agent | MIC a range (μg/mL) | MIC 50 b (μg/mL) | MIC 90 c (μg/mL) | No. (%) of isolates susceptible |
|---|---|---|---|---|
| Tigecycline |
3-32 |
6 |
8 |
|
| Ciprofloxacin |
<0.25 to >4 |
2 |
>4 |
15 (42) |
| Levofloxacin |
0.5 to >8 |
>8 |
>8 |
14 (39) |
| Ampicillin-sulbactam |
8 to >32 |
>32 |
>32 |
2 (6) |
| Piperacillin-tazobactam* |
8 to >128 |
32 |
>128 |
12 (48) |
| Cefazolin |
<1 to >64 |
>64 |
>64 |
13 (36) |
| Ceftriaxone |
<1 to >64 |
<1 |
>64 |
21 (58) |
| Ceftazidime |
<1 to >64 |
16 |
>64 |
16 (44) |
| Cefepime |
<1 to >64 |
<1 |
>64 |
23 (64) |
| Amikacin |
<2 to >64 |
<2 |
16 |
33 (92) |
| Gentamicin |
<1 to >16 |
<1 |
>16 |
22 (61) |
| Ertapenem |
<0.5 to >8 |
<0.5 |
4 |
28 (78) |
| Imipenem | <0.25 to 4 | <1 | <1 | 34 (94) |
aMIC: minimal inhibitory concentration.
bMIC50: MIC for 50% of isolates.
cMIC90: MIC for 90% of isolates.
*Total number is 25 because 11 patients did not undergo the MIC test.