Fig. 7.

Outline of discovery process of novel family of PPAR-γ partial agonists. A, Conformation of compound 6 bound to active site of PPAR-γ was used as a pharmacophore. B, The bound conformation of compound 6 was used to screen the compound library. Compound 7 identified as a hit in the compound library screen. The binding mode of compound 7 obtained through docking study was used to define a core structure that was used for further similarity search which identified compound 1 as a potent agonist of PPAR-γ. From Lu et al. (2006).