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. 2013 Nov 19;22(1):10–17. doi: 10.1038/mt.2013.230

Figure 7.

Figure 7

Molecular and biochemical characterization of livers from AAV posttreated, ketogenic diet (KD)-fed mice. (a) Viral DNA content in livers. (b) Mitochondrial DNA (MtDNA) analysis. Note that mtDNA content in AAV-treated Mpv17−/− is higher than in untreated littermates, but remains lower than in control littermates. (c) Mitochondrial transcripts analysis. (d) Cytochrome c oxidase histochemical staining in b and c. The asterisks (*) indicate significance (P) calculated by the Mann–Whitney test for independent samples; **P < 0.001; ***P < 0.001. Color codes: solid blue: untreated Mpv17+/−; blue outline: AAV-treated Mpv17+/; solid red: Mpv17−/−; red outline: AAV-treated Mpv17−/−. Bars indicate the standard deviation (SD).