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In vivo therapeutic efficacy of compound 19 compared to 1 in inhibiting growth of xenograft tumors (triple-negative breast cancer cell line MDA-MB-231) in mice (i.p.) at 5 mg/kg: (A) average tumor size changes; (B) average body weight changes. Values are mean ± SE of three independent experiments. Statistical significance was determined using one-way ANOVA (p < 0.0001).
