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. Author manuscript; available in PMC: 2014 Oct 24.
Published in final edited form as: J Med Chem. 2013 Oct 8;56(20):10.1021/jm401217d. doi: 10.1021/jm401217d

Scheme 2.

Scheme 2

Syntheses of the Urea and Carbamate Derivatives of 3a

a Reagents and condition: (a) PNP-chloroformate, CH2Cl2, 0 °C, 30 min. (b) MeNH2, THF, room temperature, 15 min, 53% in two steps. (c) TEA, alkyl isocyanate, THF, room temperature, 24 h, 55–61%. (d) NMM, alkyl chloroformate, THF, 0 °C, 20 min, 49–80%.