Table 1.
Univariate analysis of predictors of mortality in patients with severe anterior circulation stroke
| Overall (%) | In-hospital morality subgroup | Survivors only subgroup | p value | |
|---|---|---|---|---|
| Total patients | 46 (100) | 13 (28.2) | 33 (71.7) | |
| Age, mean ± SEM (years) | 57.3 ± 1.6 | 60.8 ± 2.9 | 55.9 ± 1.8 | 0.17 |
| Sex, male | 17 (37.0) | 3 (23.1) | 14 (42.4) | 0.23 |
| NIHSS score | 20.9 ± 0.5 | 21.3 ± 0.8 | 20.7 ± 0.6 | 0.59 |
| Infarct volume (ml) | 152.0 ± 11.6 | 189.7 ± 27.0 | 137.1 ± 11.5 | 0.05* |
| Nadir sodium (mmol/L) | 136.4 ± 0.4 | 136.0 ± 1.0 | 136.6 ± 0.4 | 0.51 |
| Peak sodium (mmol/L) | 146.1 ± 1.0 | 148.6 ± 2.4 | 145.2 ± 1.0 | 0.12 |
| Hyperosmolar therapy | 25 (54.3) | 10 (77.0) | 15 (45.5) | 0.06 |
| Bolus ICP treatment | 14 (30.4) | 7 (53.8) | 7 (21.2) | 0.04* |
| Decompressive craniectomy | 9 (19.5) | 1 (7.7) | 8 (24.2) | 0.23 |
| GCS score decline | 15 (32.6) | 6 (46.2) | 9 (27.3) | 0.22 |
| Hemisphere, left | 34 (73.9) | 11 (84.6) | 23 (69.7) | 0.31 |
| Admission GCS score | 10.7 ± 0.4 | 9.5 ± 0.7 | 11.2 ± 0.5 | 0.07 |
| Midline shift (mm) | 4.6 ± 0.6 | 5.1 ± 1.3 | 4.4 ± 0.7 | 0.61 |
| ACA involvement | 8 (17.4) | 5 (38.5) | 3 (9.1) | 0.03* |
| Ejection fraction | 58.9 ± 2.1 | 60.5 ± 3.8 | 58.3 ± 2.5 | 0.62 |
Significant
A univariate logistic regression analysis was used to analyze independent predictors of mortality in patients with severe anterior circulation stroke. Individual predictors of mortality were identified as infarct volume, administration of bolus ICP treatment in the form of either mannitol or 23.3% hypertonic saline, and anterior cerebral artery involvement. Values are represented either as either number of patients (percentage of total patients) or as mean ± standard error of the mean. P value corresponds to all patients (column = “overall”).
Abbreviations: NIHSS= National Institutes of Health stroke scale; ICP= Intracranial pressure; GCS= Glasgow coma scale; ACA= Anterior cerebral artery