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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Gene Ther. 2013 Nov 14;21(1):96–105. doi: 10.1038/gt.2013.64

Figure 3.

Figure 3

Analysis of onset of GFP expression. Two masked observers graded fluorescent fundus images to evaluate the onset of GFP expression following vector injection. The results from the two observers were positively correlated (R2 = 0.61; A). There was no statistically significant difference in onset between capsid-mutant vectors and control vectors from an intravitreal injection or between AAV2(quad Y-F) and control scAAV5 from a subretinal injection (B; paired t-test). scAAV8(Y733F) had a significantly faster onset than the control scAAV5 following subretinal injection (B; paired t-test). Subretinal injection of the capsid-mutant vectors resulted in a faster onset of expression than intravitreal injection (B; one-way ANOVA with Bonferroni post-test). Two individual bars are shown for the control vector scAAV5 to reflect the data from the paired eye for the AAV2(quad Y-F) and the scAAV8(Y733F) groups separately. ** p <0.01, *** p <0.001