Table 1.

Core-to-Sulfonamide Linkages.

Cmpd	R	NS5B Enzyme IC50 (nM)a	GTla-Replicon EC50 (nM)b	GT1b-Replicon EC50 (nM)b
2	H	435	8260	3860
3		45	--	912
4		1	44	30
5		2	48	9
6		23	1560	278
7		40	1170	218
8		40	861	196
9		6	61	38
10		4	6	1
11		15	84	53
12		9	28	13
13		1	2	1

^aIC₅₀ measured using GT 1b, Conl strain (n ≥ 2)

^bEC₅₀ measured using GT 1a or GT 1b stable HCV subgenomic replicon (n ≥ 2).