. Author manuscript; available in PMC: 2014 Oct 24.

Published in final edited form as: J Med Chem. 2013 Oct 10;56(20):10.1021/jm401266k. doi: 10.1021/jm401266k

Table 7.

tert-Butyl substitution effect on in vitro and in vivo stability.^a

Cmpd	HLM	HH	RLM	RH	i.v. Cl
24	22 (M)	2 (H)	74 (M)	21 (M)	50 (L)
25	19 (M)	2 (H)	28 (M)	13 (M)	--
26	17 (M)	--	77 (M)	--	--
27	--	9 (M)	--	27 (M)	--

refer to Table 5 for explanation of abbreviations.