Table 9.
In vivo pharmacokinetics for 19 in rat.
| Dose / Route | Clb | Vdssc | t 1/2 d | C max e | AUCf | %F |
|---|---|---|---|---|---|---|
| 0.5 mg/kg i.v. | 17.4 | 5.12 | 5.3 | 281 | 470 | -- |
| 2 mg/kg p.o., suspension | -- | -- | -- | 12.7 | 138 | 7.2 |
| 20 mg/kg p.o., suspension | -- | -- | -- | 32.4 | 407 | 2.2 |
| 50 mg/kg p.o., nanosuspension | -- | -- | -- | 104 | 1370 | 2.9 |
| 14 mg/kg p.o., solutiona | -- | -- | -- | 398 | 4460 | 33 |
| 50 mg/kg p.o., solutiona | -- | -- | -- | 817 | 10100 | 21 |
a
1:1 PEG 400 / Labrasol
b
clearance, mL/min/kg
c
volume of distribution at steady state, L/kg
d
half-life, hr
e
peak concentration, ng/mL
f
area under curve, ng·h/mL.